Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS
نویسندگان
چکیده
Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS studyPRIMID AS Anvesha Singh, Michael Jerosch-Herold, John P Greenwood, Colin Berry, Dana K Dawson, Chim C Lang, Damian J Kelly, David Sprigings, Jeffrey P Khoo, Kai Hogrefe, Richard P Steeds, Vijay Anand Dhakshinamurthy, Gerry P McCann
منابع مشابه
Rationale and design of the PRognostic Importance of MIcrovascular Dysfunction in asymptomatic patients with Aortic Stenosis (PRIMID-AS): a multicentre observational study with blinded investigations
INTRODUCTION Aortic stenosis (AS) is the commonest valve disorder in the developed world requiring surgery. Surgery in patients with severe asymptomatic AS remains controversial. Exercise testing can identify asymptomatic patients at increased risk of death and symptom development, but with limited specificity, especially in older adults. Cardiac MRI (CMR), including myocardial perfusion reserv...
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Degenerative aortic stenosis (AS) is one of the most common valvular diseases in developed countries. AS is a progressive disease for which the only effective treatment is surgical or transcatheter aortic valve replacement (AVR). Patients with mild to moderate AS require no specific valve treatment, whereas AVR is indicated in patients with severe symptomatic AS. The main conundrum in the manag...
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Background Myocardial perfusion and strain (in particular longitudinal strainLS) are reduced in severe aortic stenosis (AS). It is thought that reduced perfusion occurs in the subendocardium secondary to increased LV pressure, leading to fibrosis and reduced LS. This relationship between perfusion, diffuse fibrosis and multidirectional myocardial strain has not been previously investigated in m...
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This study evaluated the relationship between the location of the most severe coronary artery stenosis and the subsequent acute myocardial infarction (AMI). Methods: Of 1590 patients who were admitted with a diagnosis of AMI, we identified 44 patients who had undergone previous myocardial perfusion SPECT. Thirty-one of these patients also had previous coronary angiography. The relationshi...
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عنوان ژورنال:
دوره 18 شماره
صفحات -
تاریخ انتشار 2016